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ON THE ORIGIN OF LUNG CANCER DEVELOPMENT.

L S Bolgova1, T N Tuganova1, O I Alekseenko1

  • 1National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine.

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Summary

The origin of lung cancer (LC) remains unclear despite extensive research. Further studies are needed to understand LC histogenesis for early diagnosis and screening.

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Area of Science:

  • Oncology
  • Pathology
  • Molecular Biology

Background:

  • Histogenesis of lung cancer (LC) has been investigated through various experimental, pathological, immunohistochemical, and molecular-biological studies.
  • Despite significant research efforts, the precise origin and developmental pathways of lung cancer remain ambiguous.
  • Current understanding of LC development is largely hypothetical, necessitating further scientific inquiry.

Purpose of the Study:

  • To review existing research on lung cancer histogenesis.
  • To highlight the need for definitive data on the origin of lung cancer.
  • To underscore the importance of clarifying LC origin for advancing early diagnosis and screening.

Main Methods:

  • Review of experimental studies.
  • Analysis of pathological findings.
  • Examination of immunohistochemical and molecular-biological data.

Main Results:

  • Existing studies provide significant data but no consensus on lung cancer origin.
  • The histogenesis of lung cancer is not yet fully understood.
  • Current knowledge on LC development is based on hypothetical models.

Conclusions:

  • Unambiguous data on lung cancer origin is lacking.
  • Further in-depth research is crucial to elucidate LC histogenesis.
  • Clarifying the origin of lung cancer is essential for developing effective early diagnosis and screening strategies.