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Investigations of Bis(alkylthiocarbamato)copper Linkage Isomers
Kritika Bajaj1, Sarah A Andres2, Dillon T Hofsommer1
1Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, United States.
Abstract:
Linkage isomers are coordination compounds with the same composition but different donor atoms, resulting in distinct physical and electronic structures. A pair of linkage isomers, CuL and CuL, derived from phenylglyoxal bis(ethylthiocarbamate) were synthesized, isolated, and characterized by structural, electrochemical, and spectroscopic methods. The isomers are stable in solution under ambient conditions, but CuL converts to CuL in acid, consistent with quantum-chemical calculations. The complexes were screened against a lung adenocarcinoma cell line (A549) and a nonmalignant lung fibroblast cell line (IMR-90) to evaluate the antiproliferation activity. CuL and CuL possessed EC50 values of 0.113 ± 0.030 and 0.115 ± 0.038 μM for A549 and 1.87 ± 0.29 and 0.77 ± 0.22 μM for IMR-90, respectively.
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