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Updated: Sep 23, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
Published on: May 17, 2024
Study of the Antihypertensive Effect of Laurus nobilis in Rats
Ismail Bouadid1, Ayoub Amssayef1, Mohamed Eddouks1
1Department of biology, Moulay Ismail University of Meknes, Errachidia, Morocco.
Aims:
The study aimed to study the antihypertensive activity of Laurus nobilis.
Background:
Laurus nobilis L. is used to treat hypertension in Morocco.
Objective:
The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.
Materials And Methods:
The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.
Results:
A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.
Conclusion:
The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.
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