Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pregnancy: an overfill or underfill state.

R W Schrier, J A Dürr

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |April 1, 1987
    PubMed
    Summary

    Pregnancy involves fluid shifts, with two main theories: "overfill" (kidney retention first) and "underfill" (vascular changes first). Evidence supports the "underfill" hypothesis, suggesting hormonal influences on kidney function during pregnancy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles.

    Neuroscience·2003
    Same author

    Diabetic nephropathy: pathogenesis, diagnosis, and prevention of progression.

    Advances in internal medicine·2001
    Same author

    Update on peripheral arterial vasodilation, ascites and hepatorenal syndrome in cirrhosis.

    Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2000
    Same author

    Pathogenesis and management of hyponatremia.

    The American journal of medicine·2000
    Same author

    Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis.

    American journal of physiology. Renal physiology·2000
    Same author

    Treating high-risk diabetic hypertensive patients with comorbid conditions.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2000

    Area of Science:

    • Physiology
    • Renal Physiology
    • Reproductive Physiology

    Background:

    • Pregnancy is characterized by significant alterations in fluid volume, cardiac output, and renal function.
    • Two competing hypotheses, the "overfill" and "underfill" hypotheses, attempt to explain the observed physiological changes.
    • Understanding these mechanisms is crucial for managing pregnancy-related fluid and electrolyte balance.

    Purpose of the Study:

    • To evaluate the "overfill" versus "underfill" hypotheses regarding fluid and electrolyte balance during pregnancy.
    • To investigate the role of the renin-angiotensin-aldosterone (RAA) system and vasopressin in pregnancy-induced physiological changes.
    • To explore the hormonal regulation of renal hemodynamics during gestation.

    Main Methods:

    • Review of existing literature on physiological changes during pregnancy.
    • Analysis of data from pregnant rat models, including fluid intake, blood pressure, and sodium balance.
    • Examination of hormonal system activation (RAA system, vasopressin) in response to physiological stimuli.

    Main Results:

    • Evidence supports the "underfill" hypothesis, indicating primary vascular compartment expansion.
    • Activation of the RAA system and altered vasopressin regulation are observed.
    • Pregnant rats exhibit worsened hyponatremia with sodium restriction compared to virgin rats.

    Conclusions:

    • The "underfill" hypothesis provides a better framework for understanding pregnancy-related fluid shifts.
    • Hormonal influences during pregnancy likely mediate enhanced renal hemodynamics (increased GFR and RBF).
    • The specific hormones responsible for these renal hemodynamic changes require further investigation.

    Related Experiment Videos