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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications
Yiwen Liu1, Yujing Wu1, Jinming Liu1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
International Journal of Pharmaceutics
|May 13, 2022
Summary
Deep eutectic solvents (DESs) offer unique properties for pharmaceutical applications. This review highlights their use in drug delivery for improved solubility, permeability, and bioavailability across various administration routes.
Area of Science:
- Green Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Deep eutectic solvents (DESs) are gaining prominence due to their biocompatibility, stability, and tunable properties.
- DESs are increasingly utilized in the pharmaceutical industry for active compound extraction and enhancing drug properties.
Purpose of the Study:
- To review the fabrication methods for DESs, including their advantages and limitations.
- To highlight the diverse pharmaceutical applications of DESs as drug delivery systems.
Main Methods:
- Literature review of recent advancements in DESs.
- Analysis of fabrication techniques for DES-based drug delivery systems.
- Compilation of pharmaceutical applications and case studies.
Main Results:
- DESs demonstrate significant potential in improving drug solubility and permeability.
- Various administration routes (nasal, transdermal, oral) benefit from DES-based drug delivery.
- DESs offer enhanced bioavailability for pharmaceutical compounds.
Conclusions:
- DESs represent a versatile platform for advanced drug delivery systems.
- Further research into DES fabrication and application can optimize drug efficacy and patient outcomes.
- The unique characteristics of DESs position them as key components in future pharmaceutical innovations.
