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Updated: Sep 23, 2025
07:30
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
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Sepsis Management for the Nephrologist.
Sharad Patel1, Nitin Puri2, R Phillip Dellinger2
1Department of Critical Care, Rowan University Cooper Medical School, Camden, New Jersey.
Summary
Sepsis management has evolved, focusing on immune response to infection causing organ dysfunction. Early recognition and intervention, including fluid resuscitation and vasopressors, are key for treating sepsis and septic shock.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Nephrology
Background:
- Sepsis definition has evolved over 30 years.
- Sepsis is a dysregulated immune response to infection causing organ dysfunction.
- Septic shock involves hypotension, vasopressor use, and elevated lactate.
Purpose of the Study:
- To review current literature on optimal initial resuscitation for sepsis.
- To provide a nuanced understanding of lactate physiology in sepsis.
- To discuss steroid, vasopressor, and blood purification therapies for sepsis.
Main Methods:
- Literature review and synthesis of current thought.
- Analysis of physiological and practical aspects of sepsis management.
- Inclusion of discussions on lactate, steroids, vasopressors, and blood purification.
Main Results:
- Early recognition and intervention are crucial for sepsis management.
- Understanding lactate physiology is important for sepsis care.
- Steroid and vasopressor therapies are vital components of sepsis treatment.
Conclusions:
- Optimal initial resuscitation strategies for sepsis are critical.
- Comprehensive knowledge of sepsis pathophysiology and treatment modalities is essential.
- Emerging therapies like blood purification warrant consideration in sepsis management.
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