Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

942
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
942
Forced Oscillations01:06

Forced Oscillations

6.8K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
6.8K
Oscillations about an Equilibrium Position01:04

Oscillations about an Equilibrium Position

5.7K
Stability is an important concept in oscillation. If an equilibrium point is stable, a slight disturbance of an object that is initially at the stable equilibrium point will cause the object to oscillate around that point. For an unstable equilibrium point, if the object is disturbed slightly, it will not return to the equilibrium point. There are three conditions for equilibrium points—stable, unstable, and half-stable. A half-stable equilibrium point is also unstable, but is named so...
5.7K
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.2K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.2K
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

322
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
322
Damped Oscillations01:07

Damped Oscillations

6.1K
In the real world, oscillations seldom follow true simple harmonic motion. A system that continues its motion indefinitely without losing its amplitude is termed undamped. However, friction of some sort usually dampens the motion, so it fades away or needs more force to continue. For example, a guitar string stops oscillating a few seconds after being plucked. Similarly, one must continually push a swing to keep a child swinging on a playground.
Although friction and other non-conservative...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient <sup>15</sup>N hyperpolarization of [<sup>15</sup>N<sub>3</sub>]metronidazole antibiotic via spin-relayed pulsed SABRE-SHEATH.

Journal of magnetic resonance open·2026
Same author

Angle-resolved Measurements Reveal the Origin of Signal Anisotropy in Pump-probe Microscopy.

bioRxiv : the preprint server for biology·2026
Same author

Investigation of <sup>15</sup>N-SABRE hyperpolarization at high pressures and in supercritical fluids.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2025
Same author

Exchange-selective excitation pulses for dynamic magnetic resonance.

Science advances·2025
Same author

Alexander Pines and the end of an era.

Science advances·2025
Same author

The frontiers of chemical imaging.

Science advances·2024
Same journal

Active learning-driven global search for neutral gold clusters <i>via</i> neural network potential.

Physical chemistry chemical physics : PCCP·2026
Same journal

Development of indole-based hydration-sensitive fluorescent nucleoside analogues: experimental and computational studies.

Physical chemistry chemical physics : PCCP·2026
Same journal

Gradient engineering enabled thermoelectric performance optimization in LaP/LaAs heterostructures.

Physical chemistry chemical physics : PCCP·2026
Same journal

Barrierless proton and hydrogen atom migrations in photoionized benzaldehyde clusters result in benzyl alcohol formation: an ion-molecule perspective.

Physical chemistry chemical physics : PCCP·2026
Same journal

Weakly protonated polyethylenimine induces SiC flocculation in alkaline suspensions.

Physical chemistry chemical physics : PCCP·2026
Same journal

Accurate interdomain contacts in a mixed folded protein from NMR-guided coarse-grained simulations.

Physical chemistry chemical physics : PCCP·2026
See all related articles

Related Experiment Video

Updated: Sep 23, 2025

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier
10:17

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier

Published on: July 12, 2017

11.7K

SABRE enhancement with oscillating pulse sequences.

Xiaoqing Li1, Jacob R Lindale2, Shannon L Eriksson2,3

  • 1Department of Physics, Duke University Durham, NC 27708, USA. xiaoqing.li@duke.edu.

Physical Chemistry Chemical Physics : PCCP
|May 13, 2022
PubMed
Summary
This summary is machine-generated.

Signal Amplification by Reversible Exchange (SABRE) methods were enhanced using oscillating pulse sequences. This approach triples polarization for hyperpolarized molecules, improving robustness and efficiency in magnetic resonance applications.

More Related Videos

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

7.7K
High-speed Continuous-wave Stimulated Brillouin Scattering Spectrometer for Material Analysis
07:55

High-speed Continuous-wave Stimulated Brillouin Scattering Spectrometer for Material Analysis

Published on: September 22, 2017

10.3K

Related Experiment Videos

Last Updated: Sep 23, 2025

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier
10:17

20 mJ, 1 ps Yb:YAG Thin-disk Regenerative Amplifier

Published on: July 12, 2017

11.7K
Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

7.7K
High-speed Continuous-wave Stimulated Brillouin Scattering Spectrometer for Material Analysis
07:55

High-speed Continuous-wave Stimulated Brillouin Scattering Spectrometer for Material Analysis

Published on: September 22, 2017

10.3K

Area of Science:

  • Magnetic Resonance
  • Quantum Control
  • Physical Chemistry

Background:

  • Signal Amplification by Reversible Exchange (SABRE) is a technique for hyperpolarizing molecules in solution.
  • Existing SABRE methods are effective but can be improved for efficiency and robustness.
  • Heteronuclear SABRE (X-SABRE) extends hyperpolarization to a wider range of nuclei.

Purpose of the Study:

  • To develop novel oscillating pulse sequences for enhanced hyperpolarization using SABRE.
  • To investigate the impact of magnetic field parameters and J-couplings on polarization efficiency.
  • To improve the robustness of hyperpolarization methods against experimental imperfections.

Main Methods:

  • Development and application of oscillating pulse sequences for SABRE.
  • Analysis using average Hamiltonian theory to understand J-coupling effects.
  • Computational simulations and experimental validation of the proposed methods.

Main Results:

  • Oscillating pulse sequences achieved up to triple the polarization compared to traditional methods.
  • Theoretical analysis revealed that weaker J-couplings between hydrides and target nuclei maximize polarization.
  • Waveforms with reduced time symmetry in the toggling frame enhance robustness to experimental imperfections.

Conclusions:

  • Novel oscillating pulse sequences offer a significant improvement in hyperpolarization efficiency and robustness for SABRE.
  • Understanding and controlling J-couplings is crucial for optimizing SABRE performance.
  • The developed methods provide a more reliable and effective approach for generating hyperpolarized molecules in magnetic resonance.