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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Irritable bowel syndrome: classification and pathogenesis.
Annual Review of Medicine
|January 1, 1987
Summary
Irritable bowel syndrome (IBS) is a common gut motility disorder influenced by emotional tension. While its exact causes remain unclear, psychological factors and learned behaviors play a role in IBS patients.
Area of Science:
- Gastroenterology
- Psychosomatic Medicine
Background:
- Irritable bowel syndrome (IBS) is a prevalent chronic disorder affecting gut motility.
- It impacts approximately 15% of the population in developed nations.
- Symptoms are linked to physiological changes associated with emotional tension.
Purpose of the Study:
- To explore the underlying mechanisms of Irritable Bowel Syndrome (IBS).
- To investigate the relationship between emotional tension and IBS symptoms.
- To identify potential differentiating factors in IBS patients.
Main Methods:
- Review of current knowledge on neurohumoral control of gut motility.
- Analysis of clinical features and patient behaviors in IBS.
- Comparison of IBS patients with non-patients regarding life changes and illness behavior.
Main Results:
- No pathognomonic features for IBS have been identified despite advances in understanding gut motility.
- Emotional tension is a principal driver of both intestinal and extraintestinal IBS symptoms.
- IBS patients often exhibit psychoneurotic traits and differ in learned illness behavior and experience of severe life changes.
Conclusions:
- The pathophysiology of IBS is complex, involving interplay between physiological and psychological factors.
- Learned illness behaviors and significant life changes may contribute to the manifestation and severity of IBS.
- Further research is needed to elucidate specific diagnostic markers and therapeutic targets for IBS.
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