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Updated: May 5, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
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Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

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Immune disregulation of hematopoiesis

K F Mangan

    Annual Review of Medicine
    |January 1, 1987
    PubMed

    In vitro coculture studies of normal T lymphocytes, natural killer (NK) cells, or monocytes with human hematopoietic progenitor cells (HPC) suggest a potential role for immune cells in the regulation of hematopoiesis. In some patients with severe aplastic anemia or selective pure red cell, white cell, or megakaryocyte aplasia, activated T cells, NK cells, or monocytes mediate marrow failure by suppressing growth of HPC. Immunosuppressive agents such as corticosteroids, antithymocyte globulin, cyclophosphamide, or cyclosporin A may dramatically improve blood cell production in patients with marrow failure by removing or modulating immune suppressor cells.

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