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Bioinformatics-Based Approaches to Study Virus-Host Interactions During SARS-CoV-2 Infection
Muhammad Saad Khan1, Qudsia Yousafi1, Shabana Bibi2
1Department of Biosciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Methods in Molecular Biology (Clifton, N.J.)
|May 13, 2022
Summary
Bioinformatics tools help identify SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) host interactions and potential drug targets. Further research can improve understanding of viral pathogenesis and drug development.
Area of Science:
- Virology
- Computational Biology
- Drug Discovery
Background:
- Increasing knowledge of biomolecules aids virology research.
- High-throughput sequencing generates rapid SARS-CoV-2 genomic data.
- High-throughput technologies have limitations in detailing viral pathogenesis due to complex virus-host interactions.
Purpose of the Study:
- To discuss integrative bioinformatics approaches for identifying virus-host protein interactions.
- To aid researchers in understanding SARS-CoV-2 infection mechanisms and pathogenesis.
- To explore computational aided drug design (CADD) for accelerating viral drug development.
Main Methods:
- Utilizing bioinformatics approaches to identify virus-host protein interactions.
- Identifying structurally similar proteins between humans and SARS-CoV-2.
- Predicting potential virus-host interactions.
- Applying computational aided drug design (CADD).
Main Results:
- Bioinformatics approaches can identify virus-host protein interactions.
- CADD can bridge the gap in viral drug prediction and development.
- Further research can enhance pipelines for virus-host protein-protein interactions.
Conclusions:
- Integrative bioinformatics is crucial for understanding SARS-CoV-2 pathogenesis.
- Computational methods, including CADD, are vital for efficient drug development.
- Evolutionary solutions can advance the study of virus-host interactions, host switching, and pathogen virulence.
Keywords:
Protein domain interactionProtein interaction networksSARS-CoV-2 virusStructural bioinformaticsVirus–host protein–protein interactionsMore Related Videos
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