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Post-COVID-19 vaccination inflammatory syndrome: A case report
Ibrahim Durucan1, Sabriye Guner1, Burcak Kilickiran Avci2
1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul-Cerrahpasa, Istanbul, Turkey.
Modern Rheumatology Case Reports
|May 13, 2022
Summary
A rare case of BNT162b2 mRNA vaccine-induced myositis and myocarditis in a young male is presented. This study highlights a potential, albeit uncommon, adverse effect following COVID-19 vaccination.
Area of Science:
- Immunology
- Cardiology
- Neurology
Background:
- The BNT162b2 mRNA vaccine is widely used for COVID-19 prevention.
- While generally safe, rare adverse events are being documented.
- Understanding vaccine-related complications is crucial for public health.
Observation:
- A 24-year-old male developed lower extremity pain and dark urine post-BNT162b2 vaccination.
- Clinical presentation and biopsy confirmed myositis.
- Subsequently, the patient developed exertional dyspnea and palpitations, indicative of myocarditis.
Findings:
- Laboratory tests revealed rhabdomyolysis and elevated Troponin T.
- Muscle biopsy showed necrosis and MHC class I antigen expression.
- Echocardiography demonstrated reduced ejection fraction and pericardial effusion.
Implications:
- This case suggests a rare co-occurrence of vaccine-induced myositis and myocarditis.
- It underscores the importance of monitoring for diverse cardiac and muscular adverse events post-vaccination.
- Further research is needed to elucidate the mechanisms behind these rare vaccine side effects.
