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Exercise and the aging heart.

D G Renlund, G Gerstenblith

    Cardiology Clinics
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    As people age, cardiac function during exercise is affected by reduced responsiveness to beta-adrenergic stimulation. This leads to decreased exercise heart rate and ejection fraction, impacting cardiovascular physiology in older adults.

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    Area of Science:

    • Cardiovascular Physiology
    • Exercise Science
    • Gerontology

    Background:

    • Aging impacts cardiac function during exercise, complicated by disease and lifestyle factors.
    • Distinguishing central vs. peripheral circulatory contributions to age-related changes is challenging.
    • Existing research presents conflicting findings on age-related stroke volume alterations.

    Purpose of the Study:

    • To clarify the effects of aging on cardiac function during exercise.
    • To elucidate the mechanisms behind age-related cardiovascular alterations.
    • To differentiate between central and peripheral factors influencing exercise capacity in aging.

    Main Methods:

    • Review of existing studies on age and cardiac function during exercise.
    • Analysis of factors confounding age-related cardiovascular changes.

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  • Examination of physiological responses including heart rate, stroke volume, and ejection fraction.

    • Main Results:

    • Diastolic filling is delayed at rest, but end-diastolic volume remains stable.
    • Exercise heart rate decreases with age; stroke volume findings are inconsistent.
    • End-systolic volume increases and ejection fraction diminishes in older individuals.
    • Age-associated reduced beta-adrenergic responsiveness contributes to these changes.

    Conclusions:

    • Aging leads to specific alterations in cardiac function during exercise, including reduced heart rate and ejection fraction.
    • Diminished beta-adrenergic responsiveness is a key factor in age-related cardiovascular changes.
    • Further research is needed to fully understand central and peripheral contributions to exercise capacity in aging individuals.