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Updated: Sep 23, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
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Applications of Friedel-Crafts reactions in total synthesis of natural products

Majid M Heravi1, Vahideh Zadsirjan1, Pegah Saedi1

  • 1Department of Chemistry, School of Science, Alzahra University Vanak Tehran Iran mmh1331@yahoo.com mmheravi@alzahra.ac.ir z_zadsirjan@yahoo.com +98 2188041344 +98 9121329147.

RSC Advances
|May 13, 2022
PubMed

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Several restrictions limit the use of Friedel–Crafts reactions. First, the halogen in the alkyl halide must be attached to an sp3-hybridized carbon for the Friedel–Crafts reactions to occur. Vinyl or aryl halides do not react since the carbocations formed are unstable under the reaction conditions. Second, Friedel–Crafts alkylation is susceptible to carbocation rearrangement, and the major products obtained have a rearranged carbon skeleton. In contrast, the acylium ion is...
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