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Developing Reporting Guidelines for Studies of HIV Drug Resistance Prevalence: Protocol for a Mixed Methods Study
Cristian Garcia1, Nadia Rehman1, Daeria O Lawson1
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
JMIR Research Protocols
|May 13, 2022
Summary
Developing standardized reporting guidelines for HIV drug resistance studies is crucial for accurate prevalence estimates. This research established an expert-agreed checklist to improve data quality and global health surveillance.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- HIV drug resistance poses a significant global health challenge, limiting the effectiveness of antiretroviral therapy.
- Inconsistent and inadequate data reporting in HIV drug resistance studies compromises the accuracy and usability of prevalence estimates.
- Existing research indicates a low quality of reporting in HIV drug resistance prevalence studies, necessitating improved guidance for complete and uniform reporting.
Purpose of the Study:
- To contribute to the development of standardized reporting guidelines for prevalence studies of HIV drug resistance.
- To outline the methodology employed in creating a reporting item checklist for HIV drug resistance studies.
- To identify and report key insights on essential items for reporting in HIV drug resistance prevalence studies.
Main Methods:
- A sequential explanatory mixed methods study was conducted, involving authors and users of HIV drug resistance studies.
- The study comprised a quantitative phase (cross-sectional electronic survey) followed by a qualitative phase (focus group discussions).
- Reporting items were assessed for essentiality using content validity ratios, followed by expert revision and consensus in focus groups.
Main Results:
- Data collection was completed by November 2021, with 51 participants in the electronic survey and 9 participants in two focus group discussions.
- Analysis of survey data using content validity ratios informed the selection of items for focus group discussions.
- Thematic analysis of focus group discussions was performed to identify emergent themes related to the agreement process on reporting items.
Conclusions:
- This study successfully achieved expert consensus on essential reporting items for HIV drug resistance studies, supporting the development of a reporting checklist.
- The findings will be refined by a writing committee of experts and external reviewers to finalize comprehensive reporting guidelines.
- The established guidelines aim to enhance the quality, consistency, and comparability of HIV drug resistance prevalence data globally.
Keywords:
HIVantiretroviral therapydrug resistanceglobal healthprevalenceproblemreportreporting guidelinesurveillanceMore Related Videos
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