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Updated: Sep 23, 2025

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
kc-hits: a tool to aid in the evaluation and classification of chemical carcinogens
Brad Reisfeld1, Aline de Conti1, Fatiha El Ghissassi1
1Evidence Synthesis and Classification Branch, International Agency for Research on Cancer, World Health Organization, Lyon 69372 CEDEX 08, France.
Motivation:
The evaluation of chemicals for their carcinogenic hazard requires the analysis of a wide range of data and the characterization of these results relative to the key characteristics of carcinogens. The workflow used historically requires many manual steps that are labor-intensive and can introduce errors, bias and inconsistencies.
Results:
The automation of parts of the evaluation workflow using the kc-hits software has led to significant improvements in process efficiency, as well as more consistent and comprehensive results.
Availability And Implementation:
https://gitlab.com/i1650/kc-hits.git.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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