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Updated: Sep 23, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Benzodiazepine and Z-hypnotic stewardship
1Former medical director of the Alliance for Benzodiazepine Best Practices, Portland, OR, a nonprofit resource for physicians and patients.
Many medications are not first-line treatments and require a deprescribing plan. This ensures safe and effective medication management when these agents are used.
Area of Science:
- Pharmacology
- Clinical Medicine
- Geriatrics
Background:
- Certain medications are frequently used despite not being first-line options.
- This practice can lead to potential risks and suboptimal patient outcomes.
Purpose of the Study:
- To highlight the importance of not using certain agents as first-line treatments.
- To emphasize the necessity of deprescribing plans for medications that are not first-line.
Main Methods:
- Review of clinical guidelines and prescribing data.
- Analysis of medication use patterns in various conditions.
Main Results:
- Evidence indicates that several agents are used off-label or as non-first-line therapies.
- Lack of deprescribing plans is common when these medications are initiated.
Conclusions:
- Medications not indicated as first-line treatments require careful consideration.
- Implementing deprescribing strategies is crucial for optimizing pharmacotherapy and patient safety.
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