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The Impact of Omega-3 Supplements on Non-Surgical Periodontal Therapy: A Systematic Review
Luísa Martins Miller1, Flávia Benetti Piccinin2, Ubele van der Velden3
1Post-Graduate Program, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil.
Aim:
This systematic review examined the additional effect of taking omega-3 supplements on periodontal therapy.
Methods:
The focused question was "What is the possible effect of omega-3 supplementation concomitant to non-surgical periodontal therapy on clinical periodontal parameters?" Databases Cochrane, Embase, Google Scholar, PubMed, and Web of Science (January-July 2021) were searched to identify appropriate studies. Randomized clinical trials (RCT) about non-surgical therapy with omega-3 supplementation, with at least 3 months of supplementation period were included. Cochrane risk of bias tool version 2 and Grading of Recommendations Assessment, Development, and Evaluation were used.
Results:
A total of 1556 studies were found, of which eight studies met the inclusion criteria. All eight studies evaluated periodontal probing depth and clinical attachment loss; plaque and gingival inflammation were evaluated in seven studies. High variety of omega-3 dosage, different study lengths, questionable results from periodontal therapy (including test and control groups), high risk of bias and moderate quality of evidence prevented a satisfactory conclusion regarding the benefits of omega-3 supplementation. The studies' high heterogeneity avoided meta-analysis.
Conclusion:
Notwithstanding all limitations, the promising effects of omega-3 supplementation presented in two six-month studies encourage performing RCT with better-defined treatment protocols and greater methodological rigor.
