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Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators
George Papageorgiou1, John E T Corrie2
1Chemical Biology STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Molecules (Basel, Switzerland)
|May 14, 2022
Abstract
None:
Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.
