Changes in TSH, T4, T3 and Thyroglobulin Levels throughout Total Thyroidectomy

Area of Science:

• Endocrinology
• Surgical Oncology
• Thyroidology

Background:

• Assessing the impact of total thyroidectomy on thyroid function is crucial for patient management.
• Thyroid hormone levels can fluctuate during surgical procedures.

Purpose of the Study:

• To evaluate the perioperative changes in thyroid function following total thyroidectomy.
• To determine the clinical significance of these hormonal shifts.

Main Methods:

• Monocentric observational prospective study involving 77 patients undergoing total thyroidectomy.
• Perioperative blood sampling (pre-, intra-, and post-operative) to measure TSH, T4, T3, and thyroglobulin.
• Statistical analysis of hormonal changes and correlation with clinical outcomes.

Main Results:

• Significant increases in T4 and thyroglobulin from pre- to intra-operative stages (T0 to T1).
• Significant decreases in TSH, T4, T3, and thyroglobulin from intra- to post-operative stages (T1 to T2).

Conclusions:

• Thyroid hormone levels exhibit variable kinetics during thyroid gland manipulation in surgery.
• Despite observed hormonal fluctuations, no adverse clinical effects such as thyrotoxicosis were noted.