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Related Experiment Video

Updated: Sep 23, 2025

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

Published on: June 3, 2018

Polymeric Electrochemical Sensor for Calcium Based on DNA.

Mohsen M Zareh¹, Soha F Mohamed¹, Anas M Elsheikh¹

¹Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.

|May 14, 2022

Summary

This study developed a novel calcium (Ca²⁺) selective sensor using deoxyribonucleic acid (DNA) in plastic membranes. The sensor demonstrated excellent performance and selectivity for calcium detection in various real-world samples.

Keywords:

calcium determination calcium sensor deoxyribonucleic acid ionophore

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Last Updated: Sep 23, 2025

Development of an Electrochemical DNA Biosensor to Detect a Foodborne Pathogen

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Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

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A Polyaniline-based Sensor of Nucleic Acids

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Area of Science:

Electrochemistry
Materials Science
Analytical Chemistry

Background:

Plastic membranes are crucial in sensor technology.
Deoxyribonucleic acid (DNA) shows potential as an electroactive material for ion sensing.
Developing selective and efficient calcium sensors is important for various applications.

Purpose of the Study:

To develop and characterize a novel calcium (Ca²⁺) selective sensor utilizing DNA as the electroactive material.
To optimize the membrane composition for enhanced sensor performance.
To evaluate the sensor's selectivity, response time, and applicability in real samples.

Main Methods:

Fabrication of polyvinyl chloride (PVC) based plastic membranes incorporating DNA as an ionophore.
Testing different plasticizers (DEP, DOP, NPOE) and optimizing the membrane composition (DNA: DOP: PVC).
Electrochemical characterization including calibration, pH range determination, response time, and selectivity studies.

Main Results:

A sensor with a specific composition (120 mg PVC, 60 mg DOP, 2 mg DNA) exhibited optimal performance.
The sensor achieved a slope of 30 mV decade^-1 within an optimal pH range of 5.7-9.5.
Fast response time (2-3 s), long working period (3 weeks), and excellent Ca²⁺ selectivity were observed.

Conclusions:

Plastic membranes incorporating DNA can function as effective Ca²⁺ selective sensors.
The developed sensor shows high selectivity and rapid response, making it suitable for practical applications.
The sensor was successfully applied for calcium determination in real samples like fruits, milk, and dairy products.