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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Research Progress on the Pathogenesis of Aortic Dissection

Zhi-Qiang Yin1, Hua Han2, Xianchun Yan2

  • 1Department of Cardiovascular Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University); The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shanxi, China.

Current Problems in Cardiology
|May 14, 2022
PubMed

Insights

Aortic dissection, a dangerous cardiovascular condition, is driven by inflammation and macrophage infiltration into the aortic wall. Understanding these mechanisms is key to improving patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Pathology

Background:

  • Aortic dissection is a life-threatening cardiovascular disease with high mortality.
  • Inflammation of the aortic wall is a known promoter of aortic dissection.
  • Monocyte/macrophage infiltration is implicated as a primary pathogenic mechanism.

Purpose of the Study:

  • To review the latest research on macrophage infiltration in aortic dissection.
  • To explore the role of macrophage plasticity in the pathogenesis of aortic dissection.

Main Methods:

  • Literature review of recent studies on aortic dissection.
  • Analysis of research focusing on inflammatory pathways and cellular mechanisms.
  • Synthesis of findings related to monocyte/macrophage behavior in the aortic wall.

Main Results:

  • Inflammation significantly contributes to the development and progression of aortic dissection.
  • Macrophage infiltration is a critical factor in the disease's pathogenesis.
  • Macrophage plasticity influences the inflammatory cascade within the aortic wall.

Conclusions:

  • Macrophage infiltration and plasticity are central to aortic dissection pathogenesis.
  • Further research into these mechanisms may reveal novel therapeutic targets.
  • Understanding macrophage roles is crucial for improving treatment strategies for aortic dissection.

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