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[Aspergillus mediastinitis following post-immunotherapy lobectomy for oligometastatic lung]

C Masgnaux1, H Boukhiar1, B Dakhil1

  • 1Service de chirurgie thoracique et vasculaire, hôpital Victor-Dupouy, 69, rue du Lieutnant-Colonel Prudhon, 95107 Argenteuil, France.

Revue Des Maladies Respiratoires
|May 15, 2022
PubMed

The relationship between infectious disease and therapy with immune checkpoint inhibitors remains unknown. We report the case of a 50-year-old woman with metastatic lung adenocarcinoma who responded remarkably well to immunotherapy and underwent upper right lobectomy. Three weeks after hospital discharge, she was readmitted for severe dyspnea due to mainstem bronchus compression by mediastinal mass. Histological analysis of transbronchial needle aspiration revealed A. fumigatus. After six months of voriconazole regimen, her symptoms improved with the regression of bronchial compression. Postoperative progression of pseudo-tumoral mass in patients treated with long-term immunotherapy may be related to opportunistic infectious disease and requires investigation.

Keywords:
A. fumigatusCancer bonchique non à petites cellulesImmunotherapyImmunothérapieMediastinitisMédiastiniteNon-small cell lung cancer

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