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Pseudoretinoblastoma: Distribution based on gender, age, and laterality.
Ibadulla Mirzayev1,2, Ahmet Kaan Gündüz1,3, Funda Seher Özalp Ateş4
1Department of Ophthalmology, 63990Ankara University Faculty of Medicine, Ankara, Turkey.
European Journal of Ophthalmology
|May 16, 2022
Summary
Pseudoretinoblastoma (PSRB) diagnoses vary by gender and age, with Coats disease more common in males and persistent fetal vasculature (PFV) in females. Coats disease is prevalent in older children, while PFV is more common in infants.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Medical Diagnostics
Background:
- Pseudoretinoblastoma (PSRB) encompasses various conditions mimicking retinoblastoma.
- Understanding PSRB distribution is crucial for accurate diagnosis and management.
Observation:
- A retrospective analysis of 607 patients (851 eyes) diagnosed with PSRB between 1998 and 2021.
- Patients were stratified by gender, age (≤1, >1-3, >3-5, >5 years), and laterality.
Findings:
- Coats disease was the most common PSRB in males (20.2%), while persistent fetal vasculature (PFV) was most common in females (21.3%).
- PFV was the leading diagnosis in patients ≤3 years old, whereas Coats disease predominated in those >3 years old.
- Coats disease typically presented unilaterally, while PFV, optic nerve head drusen, and retinopathy of prematurity were more commonly bilateral.
Implications:
- PSRB diagnoses exhibit significant variations based on demographic factors.
- These findings aid in differentiating between retinoblastoma and its simulators.
- Tailored diagnostic approaches considering gender, age, and laterality can improve patient outcomes.
Keywords:
Coats diseasecongenital cataractfamilial exudative vitreoretinopathyoptic nerve head drusenpersistent fetal vasculaturepseudoretinoblastomaretinal astrocytic hamartomaretinal detachmentretinoblastomaretinopathy of prematurity
