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Network Pharmacology and Bioinformatics Analyses Identify Intersection Genes of Vitamin D3 and COVID-19 as Potential

Shanglin Wang1,2, Huayu Gao3, Xiaoru Wang4

  • 1Research Center of Basic Medicine, Jinan Central Hospital, Shandong University, Jinan, China.

Frontiers in Pharmacology
|May 16, 2022
PubMed

Insights

Vitamin D3 (VD3) shows potential in treating stomach adenocarcinoma (STAD) and COVID-19 by targeting viral and inflammatory pathways. This study explored VD3

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • The COVID-19 pandemic highlights the vulnerability of cancer patients, particularly those with stomach adenocarcinoma (STAD).
  • Gastrointestinal transmission routes of SARS-CoV-2 necessitate novel therapeutic strategies.
  • Vitamin D3 (VD3) possesses known antiviral, anti-inflammatory, and immunomodulatory properties.

Purpose of the Study:

  • To investigate the potential of Vitamin D3 (VD3) as a therapeutic agent against stomach adenocarcinoma (STAD) and COVID-19.
  • To elucidate the underlying mechanisms of action for VD3 in combating STAD and COVID-19.

Main Methods:

  • Bioinformatics and network pharmacology approaches were employed for clinicopathological and protein interaction analyses.
  • Molecular docking was utilized to validate the binding affinity of VD3 to key pharmacological targets and viral proteins.
  • Enrichment analysis identified relevant biological pathways and functions.

Main Results:

  • Clinical characteristics of STAD/COVID-19 patients were analyzed.
  • VD3 demonstrated potential antiviral, anti-inflammatory, and immunomodulatory effects relevant to STAD/COVID-19.
  • Molecular docking confirmed VD3 binding to COVID-19 targets (spike RBD/ACE2, Mpro) and identified PAI1 as a core target for anti-STAD/COVID-19 activity.

Conclusions:

  • This study suggests VD3 may treat STAD/COVID-19 by targeting the SERPINE1 gene via inflammatory and viral pathways.
  • VD3 presents a novel therapeutic avenue for STAD/COVID-19 co-infection.
  • Further research into VD3's role in STAD/COVID-19 treatment is warranted.
Keywords:
COVID-19bioinformatics analysescalcitriolgastric cancermolecular dockingnetwork pharmacologyvitamin D3

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