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Bacteriospermia and its association with seminal fluid parameters and infertility in infertile men, Kerman, Iran: A

Parastou Heidari Pebdeni1, Fereshteh Saffari2, Toraj Reza Mirshekari3

  • 1Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

International Journal of Reproductive Biomedicine
|May 16, 2022
PubMed
Abstract

Insights

Genital Mycoplasma genitalium and Chlamydia trachomatis significantly impact male infertility by reducing sperm quality and volume. Early screening for these bacteria is recommended, especially in asymptomatic individuals, to improve diagnosis and treatment outcomes.

Area of Science:

  • Reproductive Medicine
  • Microbiology
  • Urology

Background:

  • The role of genital Ureaplasma species, Mycoplasma (M) species, and Chlamydia (C.) trachomatis in male infertility remains unclear, with conflicting reports on their impact on semen quality.
  • These sexually transmitted bacteria are prevalent and their association with male infertility requires further investigation.

Purpose of the Study:

  • To determine the frequency of bacteriospermia in men.
  • To investigate the relationship between the presence of Ureaplasma, Mycoplasma, and Chlamydia trachomatis and semen quality using molecular assays.

Main Methods:

  • A cross-sectional study involving 200 semen samples from men attending fertility centers in Kerman, Iran.
  • Semen analysis included volume, progressive motility, non-progressive motility, total progressive motility, and viability per WHO guidelines.
  • Polymerase chain reaction (PCR) was employed for bacterial detection.

Main Results:

  • Infertility was associated with significantly lower semen volume, progressive motility, non-progressive motility, total progressive motility, and viability.
  • Mycoplasma genitalium correlated with reduced progressive sperm motility; Mycoplasma hominis with decreased semen volume.
  • Ureaplasma parvum was linked to abnormal sperm morphology, and Chlamydia trachomatis to reduced progressive motility and viability.
  • Logistic regression identified M. genitalium (OR=8.06) and C. trachomatis (OR=16) as significantly associated with male infertility.

Conclusions:

  • Clinicians should consider the role of Chlamydia trachomatis and Mycoplasma genitalium in male infertility assessments.
  • Screening for these bacteria, particularly in asymptomatic men, is recommended for improved diagnostic and therapeutic strategies.
Keywords:
InfertilityMycoplasmaSemen analysisChlamydia trachomatisUreaplasma.

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