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3D Coaxial Bioprinting: Process Mechanisms, Bioinks and Applications
Tarun Shyam Mohan1, Pallab Datta2, Sepehr Nesaei3,4
1Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, India.
Summary
Coaxial bioprinting, a type of extrusion-based bioprinting, fabricates complex tissue constructs with vascular networks. This review covers advancements, bioinks, and applications in tissue engineering and disease modeling.
Area of Science:
- Bioprinting and Tissue Engineering
- Biomaterials Science
- Regenerative Medicine
Background:
- Bioprinting enables fabrication of tissue constructs mimicking native tissues.
- Extrusion-based bioprinting (EBB) is a widely used technique.
- Coaxial bioprinting, a specialized EBB, creates concentric cell-material layers, enhancing tissue mimicry.
Purpose of the Study:
- To review advancements in biofabrication using coaxial bioprinting.
- To focus on suitable bioinks for coaxial bioprinting.
- To analyze achievements and limitations of coaxial bioprinting in various applications.
Main Methods:
- Review of current literature on coaxial bioprinting.
- Discussion of bioink properties for coaxial bioprinting.
- Analysis of applications in tissue engineering, drug delivery, and disease modeling.
Main Results:
- Coaxial bioprinting facilitates the creation of vascularized tissue constructs.
- Suitable bioinks are crucial for successful coaxial bioprinting.
- Key achievements include advancements in tissue engineering, drug delivery, and in-vitro disease models.
Conclusions:
- Coaxial bioprinting is a versatile technique for advanced tissue engineering.
- Further research on bioinks and clinical translation is essential.
- The technique holds significant promise for regenerative medicine and disease modeling.
