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Altered Gut Microbiota in Children With Hyperuricemia.
Xin Yuan1, Ruimin Chen1, Ying Zhang1
1Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, China.
Frontiers in Endocrinology
|May 16, 2022
Summary
Children with hyperuricemia (HUA) show altered gut microbiota, with decreased beneficial bacteria and altered purine metabolism. These gut microbiome changes may contribute to elevated uric acid levels in pediatric HUA.
Area of Science:
- Microbiome research
- Pediatric health
- Metabolic disorders
Background:
- Gut dysbiosis is implicated in adult gout pathogenesis.
- Gut microbiota characteristics in children with hyperuricemia (HUA) are underexplored.
Purpose of the Study:
- Analyze gut microbiota composition in children with HUA compared to controls.
- Identify bacterial associations linked to HUA in pediatric subjects.
Main Methods:
- 80 children were categorized into HUA and control groups based on serum uric acid (UA) levels.
- Gut microbiota composition was assessed using 16S rRNA high-throughput sequencing.
- Metabolic pathway predictions were performed.
Main Results:
- Gut microbiota in the HUA group showed distinct clustering compared to controls.
- Serum UA levels positively correlated with specific bacterial genera (e.g., Actinomyces) and negatively with short-chain fatty acid (SCFA) producers (e.g., Alistipes).
- HUA subjects exhibited decreased purine biosynthesis and increased purine degradation pathways.
Conclusions:
- Gut microbiota composition differs between children with and without HUA.
- Alterations in SCFA and sulfide-producing bacteria may be associated with pediatric HUA development.
