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Lesion network mapping of mania using different normative connectomes.

Gonçalo Cotovio1,2,3, Francisco Faro Viana1,4, Michael D Fox5,6,7

  • 1Champalimaud Research and Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.

Brain Structure & Function
|May 16, 2022
PubMed
Summary

Lesion network mapping reliably identifies brain networks linked to mania, even when using different healthy brain connectomes. This neuroimaging technique

Keywords:
ConnectomeLesion network mappingManiaReproducibility

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Network Science

Background:

  • Lesion network mapping (LNM) is a neuroimaging technique that uses functional connectivity data from healthy individuals to map brain networks associated with specific syndromes.
  • LNM has provided insights into the neural mechanisms of neuropsychiatric disorders.
  • Concerns about LNM reproducibility exist due to variations in connectome databases (MRI acquisition, preprocessing).

Purpose of the Study:

  • To assess the impact of using different healthy brain connectomes on lesion network mapping results for mania.
  • To evaluate the reproducibility of LNM for mania across different connectomes.

Main Methods:

  • Utilized resting-state functional connectivity data from multiple healthy brain connectome databases.
  • Applied lesion network mapping to identify brain regions functionally connected to lesions associated with mania.
  • Compared LNM results across different connectomes to assess consistency.

Main Results:

  • Lesion network mapping results for mania were consistent and reliable, regardless of the specific connectome used.
  • The choice of connectome did not significantly alter the identified network associated with mania.

Conclusions:

  • Lesion network mapping is a robust technique for studying the neural basis of mania.
  • The findings support the reliability of LNM for investigating neuropsychiatric disorders, even with variations in underlying connectome data.