Related Experiment Video

Updated: Sep 23, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

HDL and Diabetes

Blake J Cochran1, Bikash Manandhar1, Kerry-Anne Rye2

  • 1Lipid Research Group, Faculty of Medicine, School of Medical Sciences, University of New South Wales Sydney, Sydney, NSW, Australia.

Advances in Experimental Medicine and Biology
|May 16, 2022
PubMed

Insights

High-density lipoproteins (HDLs) show promise in combating diabetes and cardiovascular disease. HDL and apoA-I improve pancreatic cell function and insulin sensitivity, offering new therapeutic avenues for cardiometabolic conditions.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Lipid Metabolism

Background:

  • Diabetes mellitus is a growing global health concern, significantly increasing cardiovascular disease (CVD) risk.
  • Diabetic patients face a 2-4 times higher risk of developing CVD.
  • Plasma high-density lipoproteins (HDLs) are explored for their potential roles in managing cardiometabolic diseases.

Purpose of the Study:

  • To investigate the anti-diabetic and cardioprotective effects of plasma high-density lipoproteins (HDLs).
  • To examine the impact of HDLs and apolipoprotein A-I (apoA-I) on pancreatic beta cell function and insulin sensitivity.

Main Methods:

  • Review of existing literature on HDL function in diabetes and cardiovascular health.
  • Analysis of the role of HDL and apoA-I in metabolic regulation.

Main Results:

  • HDLs and apoA-I enhance pancreatic beta cell function.
  • ApoA-I demonstrates a positive effect on insulin sensitivity.
  • HDL-based approaches show potential for treating cardiometabolic disorders.

Conclusions:

  • HDLs and apoA-I possess significant anti-diabetic and cardioprotective properties.
  • Novel, bifunctional HDL-based interventions represent a promising therapeutic strategy for cardiometabolic diseases.

Keywords:
AntidiabeticDiabetesInsulin sensitivityβ cell

More Related Videos

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.2K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

69.5K

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
726
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.3K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.3K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.9K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
74