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HDL and Surgery
Yue-Ming Peng1,2,3, Jing-Song Ou4,5,6
1Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Insights
High-density lipoprotein (HDL) function is crucial post-surgery. Changes in HDL amount, components, and function occur after bariatric and cardiac surgeries, impacting clinical predictions.
Area of Science:
- Cardiovascular Science
- Metabolic Surgery
- Clinical Biochemistry
Background:
- Plasma high-density lipoprotein (HDL) possesses functions beyond lipid transport.
- The role of HDL in the postsurgery period is increasingly recognized.
- Surgical interventions significantly impact physiological parameters.
Purpose of the Study:
- To summarize alterations in HDL characteristics following major surgeries.
- To highlight the functional and compositional changes in HDL post-surgery.
- To identify key HDL-related biomarkers for postsurgical outcomes.
Main Methods:
- Literature review of studies investigating HDL changes after bariatric and cardiac surgery.
- Analysis of data on HDL quantity, composition, and functional capacity.
- Evaluation of established and emerging HDL-related clinical predictors.
Main Results:
- Significant changes in HDL quantity and quality are observed after bariatric and cardiac surgeries.
- HDL components and functional properties, such as cholesterol efflux capacity, are altered.
- Specific HDL-related indices, including HDL cholesterol (HDL-C) concentration and monocyte count to HDL ratio (MHR), show predictive value.
Conclusions:
- HDL plays a critical role in the postsurgical period, with significant modifications occurring after various surgeries.
- Changes in HDL quantity, composition, and function are important considerations for patient recovery.
- HDL-derived biomarkers are valuable for predicting clinical outcomes in the postsurgery setting.
Abstract:
In addition to the well-known functions, plasma HDL also plays an important role in postsurgery periods. In this chapter, we summarized the changes of HDL after surgery like bariatric surgery and cardiac surgery. Not only the amount of HDL changed, the HDL components or functions have also been altered after various surgeries. Furthermore, a few HDL-related indexes have been recognized as important clinical predictors after surgery, such as HDL cholesterol efflux capacity, HDL pro-inflammatory index, HDL cholesterol (HDL-C) concentration, and monocyte count to HDL ratio (MHR).
