Relationship Of Serum Adiponectin Levels With Glycaemic Status In Pregnant Women

Area of Science:

• Endocrinology
• Metabolic Disorders
• Reproductive Health

Background:

• Adiponectin is a key hormone in glucose metabolism and insulin sensitivity.
• Its role in pregnancy, particularly concerning gestational diabetes mellitus (GDM), requires further investigation.
• Understanding adiponectin's impact on glycemic status during pregnancy is crucial for maternal health.

Purpose of the Study:

• To determine serum adiponectin levels in pregnant women with and without GDM in Peshawar, KPK.
• To assess the glycaemic status of these pregnant women.
• To investigate the relationship between serum adiponectin and glycemic parameters in pregnancy.

Main Methods:

• A cross-sectional study involving 100 pregnant women with GDM and 100 healthy pregnant women.
• Measurement of serum adiponectin, glycosylated hemoglobin (HbA1c), and fasting blood glucose (FBG) from blood samples.
• Statistical analysis using Pearson Correlation coefficient (r) to determine relationships.

Main Results:

• Pregnant women with GDM exhibited significantly lower serum adiponectin levels compared to healthy controls (2.2±0.2 vs. 11.25±4.8 μg/mL).
• GDM group showed significantly higher FBG (182.7±64.2 vs. 93.6±5.9 mg/dL) and HbA1c (7.4±0.1 vs. 5.4±0.1%).
• Serum adiponectin negatively correlated with FBG (r = -0.203, p=0.042) and HbA1c (r = -0.744, p=0.000) in women with GDM.

Conclusions:

• Serum adiponectin is markedly decreased in pregnant women diagnosed with GDM.
• Hypoadiponectinemia is associated with elevated glycemic status during pregnancy.
• Adiponectin levels show a significant negative correlation with FBG and HbA1c in this population.