Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

5.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

18 F-FDG PET/CT Findings in Fahr Syndrome : A Case Report.

Clinical nuclear medicine·2026
Same author

Disease-Free Survival of Patients with Stage II Stroma-Rich Colorectal Adenocarcinomas with Microsatellite Stability.

International journal of molecular sciences·2025
Same author

18 F PSMA Uptake in a Hypogastric Desmoid Tumor.

Clinical nuclear medicine·2025
Same author

Tertiary syphilis with bone involvement and lymphadenopathy detected by 18F-FDG PET/CT.

Revista espanola de medicina nuclear e imagen molecular·2025
Same author

Measuring the immeasurable: an approach of nuclear medicine activity using relative value units.

Annals of nuclear medicine·2025
Same author

A study on the optimal design of isothermal experiments in predictive microbiology.

Scientific reports·2025

Related Experiment Video

Updated: Sep 23, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

375

Increasing the confidence of 18F-Florbetaben PET interpretations: Machine learning quantitative approximation.

Ana María García Vicente1, María Jesús Tello Galán1, Francisco José Pena Pardo1

  • 1Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.

Revista Espanola De Medicina Nuclear E Imagen Molecular
|May 16, 2022
PubMed
Summary

Semiquantitative analysis of 18F-Florbetaben PET scans enhances visual assessment for amyloid-beta (Aβ) deposition in mild cognitive impairment and dementia. Patterns reveal preferential, non-uniform Aβ distribution in the brain.

Keywords:
(18)F-FlorbetabenAmyloid betaInterhemisphere differencesMachine learningPET/CTPET/TCSemiquantificationTarget regionsbeta-amiloidediferencias interhemisféricasmachine learningregiones “diana”semicuantificación

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.6K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.3K

Related Experiment Videos

Last Updated: Sep 23, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

375
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.6K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.3K

Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Alzheimer's disease and related dementias pose significant diagnostic challenges.
  • Amyloid-beta (Aβ) positron emission tomography (PET) imaging is crucial for diagnosing these conditions.
  • 18F-Florbetaben is a radiotracer used for PET imaging of Aβ.

Purpose of the Study:

  • To evaluate the added value of semiquantitative parameters in 18F-Florbetaben PET imaging.
  • To analyze patterns of 18F-Florbetaben brain deposition.
  • To correlate semiquantitative data with visual assessment for improved diagnostic accuracy.

Main Methods:

  • Retrospective multicenter analysis of 135 patients with mild cognitive impairment or dementia of uncertain origin.
  • Visual interpretation of 18F-Florbetaben PET scans by two experienced observers.
  • Semiquantification using standardized uptake value ratios (SUVRs) for cortical regions relative to reference regions.

Main Results:

  • 72 out of 135 patients were classified as positive for Aβ deposition via visual assessment.
  • Excellent interobserver agreement was achieved for visual interpretation.
  • All SUVRs were significantly higher in visually positive scans, with prefrontal and posterior cingulate areas showing the strongest correlation with visual evaluation.
  • ROC analysis indicated optimal diagnostic performance using SUVRs from specific target regions.

Conclusions:

  • 18F-Florbetaben semiquantitative parameters enhance visual classification of Aβ deposition.
  • The findings support the use of these parameters for machine learning applications in dementia diagnosis.
  • Amyloid-beta deposition, while widespread, exhibits non-uniform and asymmetric distribution patterns across cortical regions.