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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers

Zhuoying Du1,2, Fangshun Tan1,2, Jinlan Chen1,2

  • 1Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.

Current Pharmaceutical Design
|May 17, 2022
PubMed
Abstract

Insights

Maternally expressed gene 8 (MEG8) long non-coding RNA influences cancer progression. Its varied expression in different cancers suggests potential as a future therapeutic target or biomarker.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in disease.
  • Maternally expressed gene 8 (MEG8) is a lncRNA implicated in cancer development.
  • Understanding MEG8's function is crucial for cancer research.

Purpose of the Study:

  • To review the molecular mechanisms of MEG8 in various cancers.
  • To elucidate the physiological functions of MEG8 in cancer progression.
  • To assess MEG8's potential as a therapeutic target.

Main Methods:

  • Literature review of articles on MEG8, lncRNAs, and cancer.
  • Analysis of pathophysiological mechanisms of MEG8 in cancer development.
  • Summarization of MEG8's role in cancer proliferation, migration, and invasion.

Main Results:

  • MEG8 influences cancer cell proliferation, migration, and invasion.
  • MEG8 is upregulated in non-small cell lung cancer, pancreatic cancer, liver cancer, pituitary adenoma, and hemangioma.
  • MEG8 is downregulated in colorectal cancer, ovarian cancer, and giant cell tumor.

Conclusions:

  • MEG8 exhibits differential expression across various cancer types.
  • MEG8's distinct expression patterns suggest its clinical relevance.
  • MEG8 is a promising candidate for future cancer therapy and biomarker development.
Keywords:
Long non-coding RNAMEG8molecular mechanismovarian cancerpancreatic cancertherapeutic targettumorigenesis

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