Spray Drying as an Effective Method in the Development of Solid Self- Emulsifying Drug Delivery Systems

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• Lipophilic drug candidates often exhibit low bioavailability due to poor water solubility.
• Self-emulsifying drug delivery systems (SEDDS) are effective for enhancing the solubility and absorption of such drugs.
• Challenges with liquid SEDDS, including low drug loading and handling difficulties, necessitate formulation solidification.

Approach:

• This review focuses on the solidification of SEDDS using spray drying, a scalable and stable technique.
• It examines the critical role of adsorbent carriers in the formulation and drug compatibility.
• The review details the advantages, development methods, spray drying parameters, and characterization of solid SEDDS (S-SEDDS).

Key Points:

• Spray drying offers significant advantages for SEDDS, including improved scalability and stability.
• The choice of adsorbent carrier is crucial for the performance and compatibility of S-SEDDS.
• Solidified SEDDS can be further processed into tablet dosage forms, potentially increasing bioavailability and stability.

Conclusions:

• Spray drying is a viable method for producing stable and handleable solid SEDDS (S-SEDDS).
• Conversion of S-SEDDS into tablets presents a promising approach to overcome limitations of liquid SEDDS and enhance therapeutic efficacy.