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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Endocarditis complicated by anterior myocardial infarction: a case report. What the guidelines do not say]
Fulvio Cacciapuoti1, Pio Caso1, Luca Gaetano Tarquinio2
1Dipartimento di Cardiologia, Azienda Ospedaliera dei Colli - Ospedale "Monaldi", Napoli.
Insights
Acute myocardial infarction from infective endocarditis is rare but deadly. Prompt diagnosis and aspiration of septic emboli offer a viable treatment, emphasizing multidisciplinary care for better outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Vascular Medicine
Background:
- Infective endocarditis rarely causes acute myocardial infarction (AMI), leading to underdiagnosis and high mortality.
- Current guidelines lack specific recommendations for managing AMI secondary to infective endocarditis.
- Septic emboli occluding coronary arteries present a unique diagnostic and therapeutic challenge.
Observation:
- A case of acute coronary syndrome (ACS) caused by septic embolus occlusion of the left anterior descending artery is presented.
- Clinical and diagnostic findings suggestive of endocarditis in the context of ACS are examined.
- The patient was successfully treated with aspiration of the embolic material.
Findings:
- Septic emboli can mimic typical atherosclerotic coronary artery disease, complicating diagnosis.
- Aspiration thrombectomy can be an effective treatment for embolic coronary occlusion in infective endocarditis.
- Variable clinical presentations necessitate a high index of suspicion for endocarditis.
Implications:
- Early suspicion and diagnosis of endocarditis are crucial for patients presenting with ACS.
- A multidisciplinary team approach is essential for optimal diagnostic and therapeutic management.
- Further research is needed to refine treatment guidelines for this uncommon but severe complication.
Abstract:
Acute myocardial infarction is an uncommon complication of infective endocarditis, burdened by high mortality and often underdiagnosed. Due to its reduced frequency, current guidelines do not always highlight this condition or provide clear indications regarding treatment. We present a case of acute coronary syndrome induced by the occlusion of the anterior descending artery, due to a septic embolus and treated by aspiration of the embolic material. The clinical-instrumental aspects necessary to raise the suspicion of endocarditis and make the diagnosis are then examined. Subsequently, all the possible therapeutic strategies and any complications of the traditional treatment of acute coronary syndromes during infectious valve disease are analyzed. Since clinical presentation may be extremely variable, the establishment of a multidisciplinary team would allow, in these cases, a more appropriate and complete diagnostic and therapeutic management.
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