Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers
Yaqing Chen1, Erik Misselwitz1, Asger Holm Agergaard1
1Department of Chemistry and Interdisciplinary Nanoscience Centre (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus, Denmark. hbirkedal@chem.au.dk.
Chemical Communications (Cambridge, England)
|May 17, 2022
Abstract:
Self-forming double-crosslinked (DC) hydrogels were designed by incorporating enzyme-mimicking metal coordination polymer crosslinks and catechol chemistry. A macromolecular tris-histidine copper complex acted both as part of the hydrogel network and as a catalyst of catechol oxidation to induce a second hydrogel network by covalent crosslinking of catechol functionalized polymers thus giving catalytic control over hydrogel crosslinking.
