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Updated: Sep 23, 2025

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.

Kyle C Kern¹, Clinton B Wright¹, Richard Leigh^1,2

¹National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism

|May 17, 2022

Summary

This summary is machine-generated.

Diffusion tensor imaging (DTI) can detect acute stroke effects and predict cognitive function. Transient increases in free water (FW) indicate edema, while other DTI measures reflect pre-stroke brain health.

Keywords:

Acute ischemic stroke diffusion tensor imaging free water magnetic resonance imaging post-stroke cognitive impairment vascular cognitive impairment

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Last Updated: Sep 23, 2025

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Published on: July 28, 2013

Area of Science:

Neuroimaging
Neurology
Radiology

Background:

Post-stroke cognitive impairment arises from acute stroke effects and pre-existing brain health.
Diffusion tensor imaging (DTI) offers insights into brain tissue microstructure.

Purpose of the Study:

To evaluate DTI's ability to detect acute stroke effects.
To determine if DTI can predict post-stroke cognitive performance.

Main Methods:

Prospective cohort study including 74 patients with ischemic stroke or TIA.
DTI acquired at acute presentation, 24 hours, 5 days, or 30 days.
Whole-brain white-matter skeleton used for global DTI measures (MD, FA, FW, MD_tissue, FA_tissue).
Cognitive function assessed using telephone Montreal Cognitive Assessment (T-MoCA) at 30 and 90 days.

Main Results:

A transient 4.2% increase in global free water (FW) was observed between acute presentation and 24 hours, returning to baseline by 30 days.
All acute global DTI measures correlated with 30-day T-MoCA scores.
Acute global FW, MD, FA, and FA_tissue were associated with 90-day T-MoCA scores.

Conclusions:

Transient global FW elevation suggests stroke-induced interstitial edema.
Other global DTI measures likely represent pre-stroke brain health.
DTI is a valuable tool for assessing acute stroke impacts and predicting cognitive outcomes.