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Updated: Sep 22, 2025

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Effect of Complementary Nucleobase Interactions on the Copolymer Composition of RAFT Copolymerizations
Yan Kang1, Annhelen Lu1, Andrew Ellington2
1Department of Chemistry, University of Warwick, Library Road, Coventry, CV4 7AL, United Kingdom.
Abstract:
Methacryloyl-type monomers containing adenine and thymine have been successfully synthesized with good yields. The homopolymerization and copolymerization of these two new functional monomers were carried out using RAFT polymerization. The reactivity ratios of monomer pairs were measured and calculated using a nonlinear least-squares (NLLS) method, and the results confirmed that the monomer reactivities were dependent on the solvent used for polymerization. The presence and absence of hydrogen bonding affected the resultant copolymer composition where moderate alternating copolymers had a tendency to be formed in CHCl3, while in DMF, statistical copolymers were formed. Furthermore, the glass transition temperatures of the copolymers were investigated, and the self-assembly of block copolymers made in solvents with different polarity were studied.
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