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Related Concept Videos

Fetal Circulation01:14

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Sep 22, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Does placental abruption cause neonatal anemia?

Marieke A W Bruinsma1,2, Marjon A de Boer1,2, Sandra Prins3,4

  • 1Obstetrics and Gynecology, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Acta Obstetricia Et Gynecologica Scandinavica
|May 18, 2022
PubMed
Summary
This summary is machine-generated.

Placental abruption does not appear to cause neonatal anemia. Neonatal hemoglobin levels after placental abruption are comparable to reference curves, suggesting no significant fetal blood loss.

Keywords:
hemoglobinneonatal anemiaplacentaplacental abruption

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Area of Science:

  • Obstetrics
  • Neonatology
  • Perinatal Medicine

Background:

  • Placental abruption is a significant cause of perinatal complications.
  • The link between placental abruption and neonatal anemia is not well-established.

Purpose of the Study:

  • To investigate the relationship between placental abruption and neonatal anemia.
  • To determine if placental abruption increases the risk of anemia in newborns.

Main Methods:

  • Retrospective study of women diagnosed with placental abruption between 2016-2021.
  • Collected demographic and delivery outcome data.
  • Defined neonatal anemia as hemoglobin < 5th percentile for gestational age.

Main Results:

  • 65 mothers and neonates included; average gestational age 30+5 weeks.
  • Mean neonatal hemoglobin was 16.5 g/dL, comparable to reference values.
  • Only 3.6% of neonates had anemia; 9.2% received transfusions within 24 hours.

Conclusions:

  • Neonatal hemoglobin levels after placental abruption are not significantly lower than expected.
  • Severe neonatal anemia should not be anticipated following placental abruption.
  • Results suggest substantial fetal blood loss is unlikely in placental abruption cases.