Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

5.9K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
5.9K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

247
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
247
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.6K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal Fusion of Intraoperative FLIm and Preoperative PET/CT for Patient-Level Prediction of Lymph Node Metastasis in Head and Neck Cancer.

Cancers·2026
Same author

Label-free fluorescence lifetime imaging for rapid discrimination of high-grade prostate cancer in fresh biopsy cores: a feasibility study.

Journal of biomedical optics·2026
Same author

Development and Initial Evaluation of 3D-printed High Resolution Brain Phantom for PET.

IEEE transactions on radiation and plasma medical sciences·2025
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT.

European journal of nuclear medicine and molecular imaging·2025
Same author

Bayesian additive regression trees for machine learning to classify benign vs atypical lipomatous tumors on MRI.

Radiology advances·2025

Related Experiment Video

Updated: Sep 22, 2025

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.7K

Positronium Lifetime Image Reconstruction for TOF PET.

Jinyi Qi, Bangyan Huang

    IEEE Transactions on Medical Imaging
    |May 18, 2022
    PubMed
    Summary

    This study introduces a new method to improve positronium lifetime imaging resolution using existing PET scanners. This technique enhances the capture of tissue microenvironment data for better disease study and treatment selection.

    Area of Science:

    • Medical Imaging
    • Nuclear Medicine
    • Biophysics

    Background:

    • Positron emission tomography (PET) is vital in clinical and preclinical research.
    • Positronium lifetime imaging offers insights into tissue microenvironments but faces technical limitations.
    • Existing PET scanners have challenges in detecting triple coincidence events and achieving high spatial resolution for lifetime imaging.

    Purpose of the Study:

    • To develop a novel image reconstruction method for high-resolution positronium lifetime imaging.
    • To overcome the spatial resolution limitations imposed by the time-of-flight (TOF) resolution of current PET scanners.
    • To enable the use of existing TOF PET scanners for advanced positronium lifetime imaging.

    Main Methods:

    • Developed a new image reconstruction algorithm specifically for positronium lifetime imaging.

    More Related Videos

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
    08:36

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

    Published on: June 7, 2024

    400
    Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
    10:21

    Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

    Published on: August 8, 2019

    8.5K

    Related Experiment Videos

    Last Updated: Sep 22, 2025

    A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
    14:19

    A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

    Published on: February 1, 2016

    8.7K
    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
    08:36

    Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

    Published on: June 7, 2024

    400
    Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
    10:21

    Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

    Published on: August 8, 2019

    8.5K
  • Utilized data from existing Time-of-Flight (TOF) PET scanners.
  • Conducted simulation studies to validate the proposed reconstruction method.

    • Main Results:

    • The proposed method significantly improves the spatial resolution of positronium lifetime images.
    • Reconstructed image resolution surpasses the theoretical limit set by the TOF resolution of the PET scanner.
    • Demonstrated the feasibility of generating high-resolution lifetime images with existing TOF PET hardware.

    Conclusions:

    • The novel reconstruction method effectively enhances spatial resolution in positronium lifetime imaging.
    • This advancement allows for detailed in vivo analysis of tissue microenvironments using standard TOF PET scanners.
    • Improved lifetime imaging can accelerate the understanding of disease mechanisms and guide treatment strategies.