Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pipe Flowrate Measurement: Problem Solving01:28

Pipe Flowrate Measurement: Problem Solving

605
A spray tank system is engineered to uniformly distribute a pest-control liquid across plants by using a pressurized mechanism. The tank, pressurized to 150 kPa, holds the pesticide at a height of 0.80 meters. Liquid flows from the tank through a 1.9 meter pipe with a diameter of 0.015 meters, angled at 0.698 radians, ultimately reaching a 0.007 meter nozzle that sprays the pesticide. Accurate calculation of the system's flow rate is crucial to ensure uniform application, and this is...
605
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

919
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
919
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

976
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
976
Atomic Emission Spectroscopy: Instrumentation01:22

Atomic Emission Spectroscopy: Instrumentation

643
The instrumentation of atomic emission spectrometry (AES) involves various components, including atomization devices that convert samples into gas-phase atoms and ions. There are two main types of atomization devices: continuous and discrete atomizers.  Continuous atomizers, like plasmas and flames, introduce samples in a constant stream, while discrete atomizers inject individual samples using syringes or autosamplers. The most common discrete atomizer is the electrothermal atomizer.
643

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining Optimal Fractionation of Neoadjuvant Radiation in Low-Risk, Early-Stage Breast Cancer-Randomized SIGNAL Clinical Trial.

Cancers·2026
Same author

Change management considerations for orally inhaled and nasal drug products and other drug device combination products in the European Union.

Journal of pharmaceutical sciences·2026
Same author

Analytical Validation of Short-Read Genome Sequencing for Diagnostic Panel and Exome Testing.

The Journal of molecular diagnostics : JMD·2026
Same author

Supportive oncology and the USA Cancer Moonshot: academic, clinical and operational opportunities.

BMJ supportive & palliative care·2026
Same author

Repurposing insulin for Alzheimer's disease treatment: intranasal delivery of a thermoresponsive nanocarrier-based insulin formulation to the brain.

Drug delivery and translational research·2026
Same author

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer.

The Prostate·2026
Same journal

Vegetable Butter-Based Nanocarriers: Do Nanoparticulation and Quercetin Loading Modulate In vitro Cellular Effects Involved in Wound Healing?

AAPS PharmSciTech·2026
Same journal

Hot-Melt Extrusion of Bupropion with Three Ethylcellulose Grades for Pellet Feedstock Preparation and Screw-Based 3D Printing of Sustained-Release Tablets.

AAPS PharmSciTech·2026
Same journal

Enhanced Stability and Transdermal Delivery of Semaglutide Using an L-Arginine Based Dissolving Microneedle System.

AAPS PharmSciTech·2026
Same journal

The Preparation and Physicochemical Characterization of a Triple Synergistic Nanoplatform Designed for Targeted Subcutaneous Delivery of Sitagliptin with Potential for β-Cell Preservation.

AAPS PharmSciTech·2026
Same journal

Repurposing Non-oncologic Drugs via Targeted Nanocarriers for Cancer Therapy: Mechanisms, Synergistic Combinations, and Clinical Translation.

AAPS PharmSciTech·2026
Same journal

Targeting Permeability Barriers By Strategic Selection of Thiol Containing Coformer for Novel Cocrystals of Metformin.

AAPS PharmSciTech·2026
See all related articles

Related Experiment Video

Updated: Sep 22, 2025

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction
08:14

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction

Published on: September 16, 2016

17.2K

Spray Pattern and Plume Geometry Testing and Methodology: An IPAC-RS Working Group Overview.

Sherryl Baxter1, Ben Myatt2, Stephen Stein3

  • 1Inhalation Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Gothenburg, Sweden.

AAPS Pharmscitech
|May 18, 2022
PubMed
Summary
This summary is machine-generated.

Plume characterization techniques for inhaled drug products have advanced significantly. Further research and dialogue are needed to optimize their use in product development and regulatory assessment.

Keywords:
inhalationnasalplume geometryspray pattern

More Related Videos

Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics
10:39

Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics

Published on: August 5, 2020

7.0K
Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering
07:47

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

7.5K

Related Experiment Videos

Last Updated: Sep 22, 2025

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction
08:14

Measuring Spray Droplet Size from Agricultural Nozzles Using Laser Diffraction

Published on: September 16, 2016

17.2K
Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics
10:39

Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics

Published on: August 5, 2020

7.0K
Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering
07:47

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

7.5K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Technologies
  • Regulatory Science

Background:

  • Spray pattern and plume geometry characterization for orally inhaled and nasal drug products (OINDP) have evolved over two decades.
  • Technological advancements have occurred since the 1998 FDA draft guidance for Metered Dose Inhalers (MDIs) and Dry Powder Inhalers (DPIs).

Purpose of the Study:

  • To provide historical context and background on plume geometry and spray pattern characterization studies.
  • To analyze the current regulatory landscape and industry practices for OINDP plume analysis.
  • To offer insights to regulatory bodies and stakeholders through case studies and best practices.

Main Methods:

  • Review of historical development of plume characterization techniques.
  • Analysis of current regulatory context and industry survey data on testing value and application.
  • Presentation of case studies and best practices in plume geometry and spray pattern assessment.

Main Results:

  • Plume geometry and spray pattern characterization are valuable in OINDP development.
  • Industry surveys indicate significant application and perceived value of these characterization techniques.
  • Further data is required to fully understand the role of these techniques in assessing formulation characteristics.

Conclusions:

  • Continued dialogue between industry and regulatory bodies is essential.
  • Optimization of plume characterization techniques for OINDP development requires further investigation.
  • Establishing optimal use of these techniques will enhance regulatory submissions and product quality.