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Determination of L-buthionine-(S,R)-sulfoximine in plasma by high-performance liquid chromatography with
Journal of Chromatography
|January 9, 1987
Abstract:
The development of a high-performance liquid chromatography system for the analysis of L-buthionine-(S,R)-sulfoximine (BSO) in human plasma is described. o-Phthalaldehyde derivatization and fluorescence detection were used. The R- and S-BSO peaks were partially separated from each other and completely separated from the matrix components. The limit of detection for BSO was 2 micrograms/ml plasma.