Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism

Area of Science:

• Dermal toxicology and xenobiotic metabolism.
• Pharmacokinetics and dermatokinetics.
• Skin absorption and biotransformation.

Background:

• Dermal contact products contain xenobiotics that can penetrate the skin's epidermis.
• Keratinocyte metabolism can biotransform xenobiotics, potentially creating toxic metabolites.
• Xenobiotics reaching the dermis become bioavailable for systemic distribution.

Purpose of the Study:

• To review and synthesize dermatokinetics mechanisms for assessing skin xenobiotic absorption.
• To focus on skin absorption and skin metabolism as key dermatokinetic processes.
• To describe and discuss experimental models for evaluating dermatokinetics.

Main Methods:

• Review of scientific literature on dermatokinetics.
• Synthesis of mechanisms involved in skin absorption and metabolism.
• Discussion of experimental models and methods for assessing dermatokinetics.

Main Results:

• Dermatokinetics provides insights into xenobiotic action via dermal exposure.
• Skin absorption and metabolism are central to dermatokinetics.
• Various experimental models exist for evaluating dermatokinetics, each with specific applications.

Conclusions:

• Dermatokinetics is essential for understanding xenobiotic behavior after skin contact.
• Current risk assessment models may not fully account for complex interactions within the exposome.
• Further research is needed to address the combined effects of multiple chemical substances on human health.