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Updated: Sep 22, 2025

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
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Gravity and lymphodynamics.

Thomas Holm-Weber1, Rasmus Eskild Kristensen1, Sheyanth Mohanakumar1

  • 1Department of Cardiothoracic Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Physiological Reports
|May 19, 2022
PubMed
Summary
This summary is machine-generated.

Gravity significantly impacts lymphatic function. Standing increases lymphatic packet propulsion frequency and pressure within minutes, highlighting the body

Keywords:
fluid balancegravitylymphaticsnear-infrared fluorescence imagingphysiology

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Area of Science:

  • Physiology
  • Biomedical Engineering

Background:

  • The lymphatic system is crucial for fluid balance and immune function.
  • Understanding healthy lymphatic function is essential for diagnosing pathologies.
  • External factors like exercise and temperature affect lymphatic vessels.

Purpose of the Study:

  • To investigate the impact of gravity on human peripheral lymphatic function.
  • To quantify changes in lymphatic propulsion frequency, velocity, and pressure due to gravitational shifts.

Main Methods:

  • Utilized Near-Infrared Fluorescence (NIRF) imaging to assess peripheral lymphatic function.
  • Measured lymphatic packet propulsion frequency, velocity, and pressure in healthy participants.
  • Compared lymphatic parameters in supine versus upright body positions.

Main Results:

  • Lymphatic packet propulsion frequency significantly increased upon standing (0.5 to 1.2 contractions/min).
  • Lymphatic pressure increased significantly by 9 mmHg while standing.
  • Lymph velocity showed variable changes without a distinct pattern during postural change.

Conclusions:

  • The lymphatic system rapidly responds to gravitational changes.
  • Increased lymphatic propulsion frequency and pressure are key responses to upright posture.
  • NIRF imaging is a valuable tool for assessing dynamic lymphatic function.