Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Extraction: Advanced Methods

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...

Complexation Equilibria: The Chelate Effect

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...

Direct-Acting Cholinergic Agonists: Pharmacokinetics

Direct-Acting Cholinergic Agonists: Pharmacokinetics

Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Surgical outcomes of percutaneous pedicle screw fixation for unstable traumatic thoracolumbar fractures: a meta-analysis focused on randomized controlled trials from the past 15 years.

Journal of orthopaedic surgery and research·2026

Same author

Latitudinal variation in morphological patterns of lens opacity among patients with cataracts.

International ophthalmology·2026

Same author

Copper induces depressive-like behavior through neuronal lipid accumulation mediated by Lipin-1.

Neurotoxicology·2026

Same author

Association between intrarenal venous flow and postoperative acute kidney injury in cardiac surgery patients following cardiopulmonary bypass: a prospective cohort study.

BMC cardiovascular disorders·2026

Same author

Structural basis for TCR recognition of a Rac1 neoantigen arising from anchor residue mutation.

Journal of structural biology·2026

Same author

Hierarchically Chiral Silver Nanoclusters Mediated Enantioselective Glutathione Depletion and Intracellular Self-Assembly for Enhanced Anticancer Therapy.

Angewandte Chemie (International ed. in English)·2026

Search research articles

Related Experiment Video

Updated: Sep 22, 2025

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

Amidoxime functionalized chitosan for uranium sequestration in vivo.

Zhiheng Li¹, Siyi Wang², Yipu Dong³

¹Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.

Ecotoxicology and Environmental Safety

|May 19, 2022

Summary

Amidoxime functionalized chitosan (AC) effectively removes uranium in vivo, outperforming commercial drugs. This biocompatible chelator reduces uranium in kidneys and femurs, even when administered hours later.

Keywords:

Amidoxime Chitosan Sequestration Structure-activity relationship Uranium

More Related Videos

An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter

An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter

Published on: July 13, 2018

Removal of Arsenic Using a Cationic Polymer Gel Impregnated with Iron Hydroxide

Removal of Arsenic Using a Cationic Polymer Gel Impregnated with Iron Hydroxide

Published on: June 28, 2019

Related Experiment Videos

Last Updated: Sep 22, 2025

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter

An Efficient Method for Selective Desalination of Radioactive Iodine Anions by Using Gold Nanoparticles-Embedded Membrane Filter

Published on: July 13, 2018

Removal of Arsenic Using a Cationic Polymer Gel Impregnated with Iron Hydroxide

Removal of Arsenic Using a Cationic Polymer Gel Impregnated with Iron Hydroxide

Published on: June 28, 2019

Area of Science:

Biomaterials Science
Toxicology
Radiochemistry

Background:

Uranium contamination poses significant health risks.
Effective in vivo uranium chelation therapy is crucial for mitigating toxicity.
Chitosan derivatives show promise as biocompatible chelating agents.

Purpose of the Study:

To evaluate amidoxime functionalized chitosan (AC) as a chelator for in vivo uranium sequestration.
To explore the structure-activity relationship of AC in uranium removal.
To compare the efficacy and biocompatibility of AC with ZnNa3-DTPA.

Main Methods:

In vivo administration of amidoxime functionalized chitosan (AC) to assess uranium removal.
Comparison of AC with ZnNa3-DTPA (a commercial uranium mobilization drug).
Quantification of uranium deposition in kidneys and femurs post-treatment.

Main Results:

AC demonstrated excellent biocompatibility and high uranium removal efficiency via injection and oral administration.
AC reduced uranium deposition in kidneys by up to 43.6% and in femurs by up to 32.3%.
AC retained significant uranium mobilization capacity even when administered 72 hours post-exposure.

Conclusions:

Amidoxime functionalized chitosan (AC) is a promising biocompatible chelator for in vivo uranium sequestration.
AC offers a potentially superior alternative to existing uranium mobilization therapies.
Delayed administration of AC remains effective, offering therapeutic flexibility.