[Outcome in Prolonged Weaning - Results of a Regional Weaning Center]

The number of patients with prolonged mechanical ventilation is increasing. Weaning units (WU) in the German network "WeanNet" are specialized in the treatment of patients needing prolonged weaning. In this study we present outcome data on the patients in our WU from 2011 to 2015.

A distinction is made between the 4 outcome groups: 1. Successful weaning without mechanical ventilation, 2. Successful weaning with non-invasive mechanical ventilation (NIV), 3. Weaning failure with subsequent invasive ventilation and 4. Death in the WU.

In 272 patients, the following distribution within the 4 outcome groups was found: Group 1: 116 patients (42.6 %), Group 2: 52 patients (19.1 %), Group 3: 45 patients (16.5 %) and Group 4: 59 patients (21.7 %).The duration of treatment in the WU depended primarily on co-morbidities and the hemoglobin level.Despite successful weaning, the tracheostoma was completely closed in only 60.3 % of patients with continuous spontaneous breathing and 67.3 % of patients with NIV at the time of discharge from the clinic.After discharge from the WU, patients with weaning failure and subsequent invasive long-term ventilation, in contrast to patients with successful weaning, were rarely transferred to rehabilitation, but re-admitted more frequently to the clinic as emergency cases (29 %).The 1-year survival rate was 59 %. Half of the patients died in less than 2 years.

The majority of patients with prolonged mechanical ventilation are successfully weaned from the respirator in the WU. Nevertheless, the proportion of patients with weaning failure and subsequent invasive long-term out-of-hospital ventilation as well as the mortality rate in the WU and after discharge were high. The ethical implications of these observations are discussed in the paper.