Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
Aging01:26

Aging

206
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
206
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Inflammatory Response01:28

Inflammatory Response

8.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
8.9K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

72
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
72
Inflammation01:38

Inflammation

55.5K
Overview
55.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic Ensemble Learning with Transfer Learning for Fatigue Performance Prediction in Ni-Based Superalloys.

Materials (Basel, Switzerland)·2026
Same author

Vegetation-Mediated Soil Organic Carbon Differentiation and Carbon Sequestration Strategies in a Typical Wetland of the North China Plain.

Plants (Basel, Switzerland)·2026
Same author

Residual Stress Relaxation in Engineering Materials: Influencing Factors, Mechanisms, and Machine Learning-Driven Predictions.

Annals of the New York Academy of Sciences·2026
Same author

Bioactive Phytochemicals in Experimental Models of Multiple Sclerosis: Mechanisms, Efficacy, and Translational Potential.

Nutrients·2026
Same author

Short- and long-term ecological risk assessment of phthalate esters in freshwater and sediment using interspecies correlation estimation, acute-chronic ratio, and species sensitivity distribution models.

Environmental toxicology and chemistry·2026
Same author

Data-Driven Fatigue Prediction of Superalloys: A Novel Strategy Integrating Transfer Learning and Partial Label Learning for Addressing Ambiguous Data.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same journal

Single Ayahuasca administration attenuates alcohol relapse and associated behavioral, neurochemical, and oxidative alterations in rats.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same journal

Altered dorsal striatal subregional connectivity associated with distinct executive function deficits in first-episode, drug-naïve major depressive disorder: Evidence from functional connectivity and granger causality analysis.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same journal

Chronic pain and stress: unravelling the common neuroinflammatory, immune and endocrine mechanisms for novel therapeutic approaches.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same journal

Predicting anhedonia and negative cognitive processing changes after 8-week SSRIs treatment in depression from individual differential structural covariance network.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same journal

Mapping intrinsic neural timescale alterations in major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same journal

Probiotics in reducing negative symptoms of schizophrenia: A systematic review and meta-analysis.

Progress in neuro-psychopharmacology & biological psychiatry·2026
See all related articles

Related Experiment Video

Updated: Sep 22, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.2K

Age-associated alterations in immune function and inflammation.

Erin Diane Lewis1, Dayong Wu1, Simin Nikbin Meydani1

  • 1Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States of America.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|May 19, 2022
PubMed
Summary
This summary is machine-generated.

Aging causes immunosenescence, a decline in immune function, particularly T cells. This leads to increased susceptibility to infections and cancer in older adults due to impaired immunity and chronic inflammation, termed "inflammaging".

Keywords:
AgingImmune functionInfectionInflammationNeurodegenerative diseases

More Related Videos

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

7.4K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K

Related Experiment Videos

Last Updated: Sep 22, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.2K
Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

7.4K
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.4K

Area of Science:

  • Immunology
  • Gerontology
  • Cellular Biology

Background:

  • Immunosenescence describes age-related immune system changes, involving dysregulated immune function and inflammation.
  • Age impacts both innate and adaptive immunity, affecting T cell number and function, B cell responses, and inflammatory mediator concentrations.

Purpose of the Study:

  • To review age-related changes in the immune system, focusing on immunosenescence and inflammation.
  • To discuss the functional consequences of these alterations in the aged population.

Main Methods:

  • This review synthesizes existing research on immunosenescence and inflammaging.
  • It examines alterations in innate and adaptive immune cells, including T cells and B cells.
  • The review also considers changes in inflammatory mediators associated with aging.

Main Results:

  • Key findings include a decline in T cell proliferation, a decrease in naive T cells, and an increase in memory T cells with age.
  • Impaired antigen presentation, reduced antibody production, and altered B cell memory are observed.
  • A chronic, low-grade inflammatory state, termed "inflammaging," is characterized by elevated inflammatory mediators in older adults.

Conclusions:

  • Immunosenescence and inflammaging significantly impair immune function in older adults.
  • These age-related immune changes contribute to increased vulnerability to infections, cancer, and other age-related diseases.
  • Understanding these processes is crucial for developing interventions to improve healthspan in aging populations.