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Related Experiment Video

Updated: Sep 22, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
03:35

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

386

Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study.

Alessandro Masala1,2, Ilaria Di Mola1,2, Maria Cellerino3

  • 1Eye Clinic, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

Journal of Clinical Neurology (Seoul, Korea)
|May 19, 2022
PubMed
Summary
This summary is machine-generated.

Choroidal thickness (CT) did not differ in multiple sclerosis (MS) patients compared to controls. However, MS patients with a history of optic neuritis (ON) showed significantly larger CT and thinner retinal nerve fiber layer (RNFL).

Keywords:
choroidal thicknessmultiple sclerosisoptic neuritisoptical coherence tomography (OCT)

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Optic neuritis (ON) is a common initial symptom of MS, impacting visual pathways.
  • Choroidal thickness (CT) and retinal nerve fiber layer (RNFL) are potential biomarkers in MS.

Purpose of the Study:

  • To investigate choroidal thickness (CT) changes in multiple sclerosis (MS) patients.
  • To compare CT in MS patients with and without a history of optic neuritis (ON).
  • To assess the relationship between CT, ON, and RNFL thickness in MS.

Main Methods:

  • Cross-sectional study involving 96 eyes with MS and 28 healthy control eyes.
  • Enhanced-depth imaging optical coherence tomography (EDI-OCT) used for CT and RNFL assessment.
  • CT measured at multiple points around the fovea; statistical analysis using paired t-tests.

Main Results:

  • Choroidal thickness (CT) was not significantly different between MS patients and healthy controls at any measurement point.
  • Eyes with a history of optic neuritis (ON) showed larger CT compared to contralateral eyes, though not statistically significant.
  • Retinal nerve fiber layer (RNFL) was significantly thinner in both MS and ON eyes compared to controls.

Conclusions:

  • Choroidal thickness (CT) did not differ between MS and control eyes.
  • A history of optic neuritis (ON) was associated with significantly larger CT and thinner RNFL in MS patients.
  • Further research is needed to elucidate the role of the choroid in the pathophysiology of MS.