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Updated: Sep 22, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
[Operating principles, physiological effects and practical issues of high-flow nasal oxygen therapy]
C Girault1, D Boyer2, G Jolly2
1UNIROUEN, EA-3830, service de médecine intensive et réanimation, hôpitaux de Rouen, Normandie université, CHU, 76000 Rouen, France.
Heated and humidified high-flow nasal oxygen therapy (HFNO) offers an alternative to standard oxygen for acute respiratory failure (ARF). While improving oxygenation and breathing comfort, close patient monitoring remains crucial.
Area of Science:
- Respiratory Medicine
- Critical Care Medicine
- Pulmonology
Background:
- Standard oxygen therapy has limitations in treating acute respiratory failure (ARF).
- Heated and humidified high-flow nasal oxygen therapy (HFNO) has emerged as a significant advancement.
- HFNO offers improved patient comfort and physiological benefits over traditional methods.
Purpose of the Study:
- To review the technical characteristics and physiological effects of HFNO.
- To highlight the clinical applications of HFNO in ARF management.
- To emphasize the importance of continued patient monitoring during HFNO therapy.
Main Methods:
- Review of HFNO technology and its physiological impact.
- Analysis of clinical scenarios where HFNO is indicated.
- Discussion of the principles of HFNO delivery via nasal cannula.
Main Results:
- HFNO delivers up to 100% oxygen (FiO2) at high flow rates (50-70 L/min) with optimal heating and humidification.
- Physiological effects include improved oxygenation and ventilatory mechanics.
- HFNO provides significant respiratory comfort to patients.
Conclusions:
- HFNO is a valuable tool for first-line treatment of hypoxemic ARF.
- The ease of use and comfort of HFNO should not lead to complacency in patient monitoring.
- Endotracheal intubation decisions must not be delayed when clinically indicated.
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