Related Experiment Video
Updated: Sep 22, 2025
06:10
Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
Published on: May 9, 2025
454
The era of in vivo T cell engineering
Gustavo Campos Ramos1, Michael Hudecek2
1Department of Internal Medicine I, University Hospital Würzburg, and Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.
Med (New York, N.Y.)
|May 19, 2022
Abstract:
Cell therapy with genetically engineered T cells has revolutionized the treatment of malignant diseases, but its potential use beyond the realms of oncology has been underexplored. In a recent study, Rurik et al.1 built on the technologies underlying mRNA vaccines to transduce T cells in vivo, harnessing them to target cardiac fibrosis.
